RECERCA I PRODUCCIÓ CIENTÍFICA
El Servei d’Anatomia Patològica participa en múltiples assajos clínics del servei d’oncologia (ICO_Girona) i col·labora en diversos projectes d’investigació d’altres serveis de l’Hospital.
Producció científica dels últims cinc anys:
1: Ibáñez R, Roura E, Monfil L, Rodríguez LA, Sardà M, Crespo N, Pascual A,
Martí C, Fibla M, Gutiérrez C, Lloveras B, Oliveras G, Torrent A, Català I,
Bosch FX, Bruni L, de Sanjosé S. Long-term protection of HPV test in women at
risk of cervical cancer. PLoS One. 2020 Aug 27;15(8):e0237988. doi:
10.1371/journal.pone.0237988. Erratum in: PLoS One. 2020 Nov 20;15(11):e0243000.
PMID: 32853216; PMCID: PMC7451648.
2: Cuatrecasas M, Gorostiaga I, Riera C, Saperas E, Llort G, Costa I, Matias-
Guiu X, Carrato C, Navarro M, Pineda M, Dueñas N, Brunet J, Marco V, Trias I,
Busteros JI, Mateu G, Balaguer F, Fernández-Figueras MT, Esteller M, Musulén E.
Complete Loss of EPCAM Immunoexpression Identifies <i>EPCAM</i> Deletion
Carriers in MSH2-Negative Colorectal Neoplasia. Cancers (Basel). 2020 Sep
29;12(10):2803. doi: 10.3390/cancers12102803. PMID: 33003511; PMCID: PMC7599495.
3: Pilco Teran M, Merino Ribas A, Martin Alemany N, Barros Freiria X, Rubio
Casadevall J, Pérez Bueno F, García Méndez I, Castillo Devia M, Noboa Paez C,
Torguet Escuder P, Calabia Martínez J. Acute tubulointerstitial nephritis
induced by the tyrosine kinase inhibitor vandetanib. Invest New Drugs. 2021
Feb;39(1):237-239. doi: 10.1007/s10637-020-00973-8. Epub 2020 Jul 9. PMID:
32648118.
4: Ledesma-Durán A, Ortiz-Durán EA, Aragón JL, Santamaría-Holek I. Eckhaus
selection: The mechanism of pattern persistence in a reaction-diffusion system.
Phys Rev E. 2020 Sep;102(3-1):032214. doi: 10.1103/PhysRevE.102.032214. PMID:
33076036.
5: Verdura S, Cuyàs E, Cortada E, Brunet J, Lopez-Bonet E, Martin-Castillo B,
Bosch-Barrera J, Encinar JA, Menendez JA. Resveratrol targets PD-L1
glycosylation and dimerization to enhance antitumor T-cell immunity. Aging
(Albany NY). 2020 Jan 4;12(1):8-34. doi: 10.18632/aging.102646. Epub 2020 Jan 4.
PMID: 31901900; PMCID: PMC6977679.
6: Lopez-Bonet E, Buxó M, Cuyàs E, Pernas S, Dorca J, Álvarez I, Martínez S,
Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S,
Luque M, Morilla I, Stradella A, Viñas G, Cortés J, Oliveras G, Meléndez C,
Castillo L, Verdura S, Brunet J, Joven J, Garcia M, Saidani S, Martin-Castillo
B, Menendez JA. Neoadjuvant Metformin Added to Systemic Therapy Decreases the
Proliferative Capacity of Residual Breast Cancer. J Clin Med. 2019 Dec
11;8(12):2180. doi: 10.3390/jcm8122180. PMID: 31835708; PMCID: PMC6947627.
7: Dámaso E, Canet-Hermida J, Vargas-Parra G, Velasco À, Marín F, Darder E, Del
Valle J, Fernández A, Izquierdo À, Mateu G, Oliveras G, Escribano C, Piñol V,
Uchima HI, Soto JL, Hitchins M, Farrés R, Lázaro C, Queralt B, Brunet J, Capellá
G, Pineda M. Highly sensitive MLH1 methylation analysis in blood identifies a
cancer patient with low-level mosaic MLH1 epimutation. Clin Epigenetics. 2019
Nov 28;11(1):171. doi: 10.1186/s13148-019-0762-6. PMID: 31779681; PMCID:
PMC6883525.
8: Palomeras S, Diaz-Lagares Á, Viñas G, Setien F, Ferreira HJ, Oliveras G,
Crujeiras AB, Hernández A, Lum DH, Welm AL, Esteller M, Puig T. Epigenetic
silencing of TGFBI confers resistance to trastuzumab in human breast cancer.
Breast Cancer Res. 2019 Jul 5;21(1):79. doi: 10.1186/s13058-019-1160-x. PMID:
31277676; PMCID: PMC6612099.
9: Clavé S, Rodon N, Pijuan L, Díaz O, Lorenzo M, Rocha P, Taus Á, Blanco R,
Bosch-Barrera J, Reguart N, de la Torre N, Oliveras G, Espinet B, Bellosillo B,
Puig X, Arriola E, Salido M. Next-generation Sequencing for ALK and ROS1
Rearrangement Detection in Patients With Non-small-cell Lung Cancer:
Implications of FISH-positive Patterns. Clin Lung Cancer. 2019
Jul;20(4):e421-e429. doi: 10.1016/j.cllc.2019.02.008. Epub 2019 Feb 26. PMID:
30898567.
10: Dámaso E, Canet-Hermida J, Vargas-Parra G, Velasco À, Marín F, Darder E, Del
Valle J, Fernández A, Izquierdo À, Mateu G, Oliveras G, Escribano C, Piñol V,
Uchima HI, Soto JL, Hitchins M, Farrés R, Lázaro C, Queralt B, Brunet J, Capellá
G, Pineda M. Highly sensitive MLH1 methylation analysis in blood identifies a
cancer patient with low-level mosaic MLH1 epimutation. Clin Epigenetics. 2019
Nov 28;11(1):171. doi: 10.1186/s13148-019-0762-6. PMID: 31779681; PMCID:
PMC6883525.
11: Bosch-Barrera J, Oliva E, Sais E, Vásquez CA, Roselló A, Menéndez JA.
Hyperprogression after first dose of immunotherapy in a patient with
radioresistant metastasis from nonsmall cell lung cancer. Anticancer Drugs. 2019
Nov;30(10):1067-1070. doi: 10.1097/CAD.0000000000000837. PMID: 31567311.
12: Cuyàs E, Fernández-Arroyo S, Buxó M, Pernas S, Dorca J, Álvarez I, Martínez
S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez
S, Luque M, Morilla I, Stradella A, Viñas G, Cortés J, Verdura S, Brunet J,
López-Bonet E, Garcia M, Saidani S, Joven J, Martin-Castillo B, Menendez JA.
Metformin induces a fasting- and antifolate-mimicking modification of systemic
host metabolism in breast cancer patients. Aging (Albany NY). 2019 May
9;11(9):2874-2888. doi: 10.18632/aging.101960. PMID: 31076561; PMCID:
PMC6535060.
13: Cuyàs E, Buxó M, Ferri Iglesias MJ, Verdura S, Pernas S, Dorca J, Álvarez I,
Martínez S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K,
Domínguez S, Luque M, Morilla I, Stradella A, Viñas G, Cortés J, Joven J, Brunet
J, López-Bonet E, Garcia M, Saidani S, Queralt Moles X, Martin-Castillo B,
Menendez JA. The <i>C</i> Allele of <i>ATM</i> rs11212617 Associates With Higher
Pathological Complete Remission Rate in Breast Cancer Patients Treated With
Neoadjuvant Metformin. Front Oncol. 2019 Mar 28;9:193. doi:
10.3389/fonc.2019.00193. PMID: 30984619; PMCID: PMC6447648.
14: Martin-Castillo B, Pernas S, Dorca J, Álvarez I, Martínez S, Pérez-Garcia JM,
Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S, Luque M,
Stradella A, Morilla I, Viñas G, Cortés J, Cuyàs E, Verdura S, Fernández-Ochoa
Á, Fernández-Arroyo S, Segura-Carretero A, Joven J, Pérez E, Bosch N, Garcia M,
López-Bonet E, Saidani S, Buxó M, Menendez JA. A phase 2 trial of neoadjuvant
metformin in combination with trastuzumab and chemotherapy in women with early
HER2-positive breast cancer: the METTEN study. Oncotarget. 2018 Nov
2;9(86):356 87-35704. doi: 10.18632/oncotarget.26286. PMID: 30479698; PMCID:
PMC6235018.